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NEM is a small molecule that forms stable, covalent thioether bonds with sulfhydryls (e.g., reduced cysteines) keeping the sulfhydryls permanently blocked

In this review, we synthesize emerging data highlighting cell type-specific dependencies on glutathione peroxidase 4 (GPX4), solute carrier family 7 member 11 (SLC7A11), ferroptosis suppressor protein 1 (FSP1), nuclear factor erythroid 2-related factor 2 (NRF2), peroxiredoxin (PRDX), thioredoxin (TRX), iron-handling proteins, and lipid remodeling pathways, and discuss how these regulatory networks differ across CNS-resident and CNS infiltrating T cells

Fletcher EL, Phipps JA, Ward MM, Puthussery T, Wilkinson-Berka JL

Instead, it acts upstream at the pituitary level, making it useful for studying the bodys own GH-regulatory system

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10.1016/j.ctrv.2016.12.010 28 de ArajF